Protein Details: β1 (Calcium-activated potassium channel subunit beta-1)

Protein ID

ICDB_Pro_0850

Protein Name

β1 (Calcium-activated potassium channel subunit beta-1)

Gene Name

KCNMB1

Organism

Homo sapiens (Human)

Length

191 amino acids

AlphaFoldDB

AF-Q16558-F1-model_v4.pdb

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1;thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate

Sequence

MVKKLVMAQKRGETRALCLGVTMVVCAVITYYILVTTVLPLYQKSVWTQESKCHLIETNIRDQEELKGKKVPQYPCLWVNVSAAGRWAVLYHTEDTRDQNQQCSYIPGSVDNYQTARADVEKVRAKFQEQQVFYCFSAPRGNETSVLFQRLYGPQALLFSLFWPTFLLTGGLLIIAMVKSNQYLSILAAQK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Hypertension;Diastolic and Rare Genetic Renal Disease

Location

Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain; relatively high levels found in hippocampus and corpus callosum.

DOI ID

10.1016/0014-5793(96)00151-2; 10.1523/jneurosci.16-15-04543.1996; 10.1073/pnas.93.17.9200; 10.1038/ng1285; 10.1101/gr.2596504; 10.1073/pnas.100118597; 10.1126/science.285.5435.1929; 10.1152/nips.01387.2002; 10.1172/jci20347

RefSeq

NP_004128.1 [Q16558-1]